The Chile international has not featured in the league since January, when he played in the 2-2 draw at home to Tottenham, but replaces Willy Caballero for the game against the Tigers.
Kevin De Bruyne must make do with a place on the bench, where he is joined by compatriot Vincent Kompany, who is nearing a full return from injury.
De Bruyne drops among the substitutes after failing to impress in City’s last two games against Arsenal and Chelsea.
Man City XI: Bravo, Clichy, Stones, Navas, Kolarov, Toure, Delph, Sterling, Silva (c), Sane, Aguero
Subs: Caballero, Kompany, Zabaleta, Fernando, Nolito, De Bruyne, Iheanacho
Hull XI: Jakupovic, Robertson, Dawson, Ranocchia, Elmohamady, Grosicki, N’Diaye, Clucas, Markovic, Evandro, Niasse
Subs: Marshall, Meyler, Davies, Hernandez, Maloney, Diomande, Henriksen
