The striker has a minor calf issue and is not involved in the matchday squad, with the midfielder still nursing the groin injury he picked up on England duty.
Academy starlet Ben Woodburn, 17, is on the teamsheet for the first time in a competitive game.
Fellow teenager Ovie Ejaria, who made his debut in the 6-1 victory over Watford, is on the bench for a league game for the third occasion.
Liverpool starting XI: Karius, Clyne, Lovren, Matip, Milner, Henderson, Can, Wijnaldum, Mane, Coutinho, Firmino
Liverpool subs: Mignolet, Moreno, Klavan, Lucas, Ejaria, Woodburn, Origi
